Issue 18, 2014
From the journal:

RSC Advances

Titanium isopropoxide complexes supported by pyrrolyl Schiff base ligands: syntheses, structures, and antitumor activity†

Miaoshui Lin,a   Yuhua Cao,b   Hao Pei,a   Yanmei Chen,a   Jian Wu,a   Yahong Li*ac  and  Wei Liu*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215006, China
E-mail: liyahong@suda.edu.cn, Weiliu@suda.edu.cn

b Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou 215125, China

c State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China

Abstract

The syntheses, structures and antitumor activity of four titanium isopropoxide complexes supported by pyrrolyl Schiff base ligands are reported. Treatment of Ti(OiPr)4 with 2 equivalents of HL1 (HL1 = N-(1H-pyrrol-2-ylmethylene)(2-pyridinyl)methanimine), HL2 (HL2 = 2-pyrrolecarbaldmethylimine), HL3 (HL3 = N-((1H-pyrrol-2-yl)methylene)(phenyl)methanimine) and HL4 (HL4 = N-((1H-pyrrol-2-yl)methylene)-2-phenylethanimine), respectively, results in the formation of Ti(OiPr)2(L1)2 (1), Ti(OiPr)2(L2)2 (2), Ti(OiPr)2(L3)2 (3) and Ti(OiPr)2(L4)2 (4). All complexes have been characterized by elemental analyses and NMR studies. The solid-state structures of complexes 1 and 3 have been further established by single X-ray crystallography. The cytotoxicity activities of 1–4 towards the tumor cells HCT-116, PC3 and MCF-7 were measured. Complexes 1, 2 and 3 showed good antitumor properties.

Graphical abstract: Titanium isopropoxide complexes supported by pyrrolyl Schiff base ligands: syntheses, structures, and antitumor activity

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Article information

DOI
https://doi.org/10.1039/C3RA45823G
Article type
Paper
Submitted
15 Oct 2013
Accepted
22 Jan 2014
First published
23 Jan 2014

RSC Adv., 2014,4, 9255-9260

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Titanium isopropoxide complexes supported by pyrrolyl Schiff base ligands: syntheses, structures, and antitumor activity

M. Lin, Y. Cao, H. Pei, Y. Chen, J. Wu, Y. Li and W. Liu, RSC Adv., 2014, 4, 9255 DOI: 10.1039/C3RA45823G

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