Issue 13, 2014

β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s for efficient insulin delivery

Abstract

A series of cationic polymers based on β-cyclodextrin (β-CD)-conjugated amino poly(glycerol methacrylate)s (PGOHMAs) was synthesized for potential insulin delivery by forming polyelectrolyte complexes (PECs). Both linear and star-shaped poly(glycidyl methacrylate)s were functionalized with mono(6-(diethylenetriamine)-6-deoxy)-β-CD and diethylenetriamine to obtain CD-DETA-PGOHMAs and DETA-PGOHMAs, respectively. The resulting polymers were characterized by 1H NMR, FT-IR, elemental analysis, and TGA, and then used to prepare PECs with insulin. The association efficiency and loading capacity of CD-DETA-PGOHMAs were higher than those of DETA-PGOHMAs. The release of insulin depended on the introduction of β-CDs, the backbone architecture of the polymers, as well as the pH. The competitive binding release study indicted that insulin could be released rapidly when 1-aminoadamantane hydrochloride (ADA) was used as a competitive binding guest molecule. The in vitro cytotoxicity study revealed that CD-series polymers have much lower toxicity than the D-series. The CD-DETA-PGOHMA/insulin complexes, with lower cytotoxicity and proper release rate, showed great potential for insulin controlled release.

Graphical abstract: β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s for efficient insulin delivery

Supplementary files

Article information

Article type
Paper
Submitted
29 Nov 2013
Accepted
20 Dec 2013
First published
20 Dec 2013

RSC Adv., 2014,4, 6478-6485

β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s for efficient insulin delivery

L. Wang, Y. Yang, M. Zhu, G. Qiu, G. Wu and H. Gao, RSC Adv., 2014, 4, 6478 DOI: 10.1039/C3RA47150K

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