A series of novel fluorescent pyrazoline coumarin derivatives were synthesized. From them, we screened a compound possessing strong growth inhibitory effects on lung cancer cells. By taking advantage of fluorescence combined with LC-MS/MS and chemoinformatics technique, we successfully identified HSP90 as the target of the compound.
S. Bai, X. Dai, B. Zhao and J. Miao, RSC Adv., 2014, 4, 19887 DOI: 10.1039/C4RA01800A
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