Issue 53, 2014

Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes

Abstract

A highly enantioselective copper-catalyzed hydrophosphonylation of aldehydes in the presence of bis(oxazoline) ligand is presented. The reaction proceeded smoothly under mild conditions. The resulting α-hydroxyphosphonates were obtained with high yields as well as enantioselectivities (up to 98% ee).

Graphical abstract: Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
11 Apr 2014
Accepted
09 Jun 2014
First published
30 Jun 2014

RSC Adv., 2014,4, 27853-27856

Author version available

Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes

T. Deng and C. Cai, RSC Adv., 2014, 4, 27853 DOI: 10.1039/C4RA03269A

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