Issue 82, 2014
From the journal:

RSC Advances

Palladium and copper-catalyzed ligand-free coupling of phenylhydrazines in water†

Parul Chauhan,‡a   Makthala Ravi,‡a   Shikha Singh,a   Kanumuri S. R. Raju,c   Vikas Bajpai,b   Brijesh Kumar,b   Wahajuddinc  and  Prem. P. Yadav*a  

* Corresponding authors

a Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow-226031, India
E-mail: pp_yadav@cdri.res.in, ppy_cdri@yahoo.co.in
Fax: +91-522-2623405/2623938
Tel: +91-522-2612411-18 ext. 4761/4762

b Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow-226031, India

c Division of Pharmacokinetics and Metabolism, CSIR-Central Drug Research Institute, Lucknow-226031, India

Abstract

An efficient protocol has been developed for the synthesis of biaryls via Pd/Cu catalyzed coupling of phenylhydrazines in water. Homo and cross couplings were successfully achieved in a ligand-free catalytic system, at room temperature with water as sole reaction medium.

Graphical abstract: Palladium and copper-catalyzed ligand-free coupling of phenylhydrazines in water

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Article information

DOI
https://doi.org/10.1039/C4RA04621H
Article type
Communication
Submitted
16 May 2014
Accepted
04 Sep 2014
First published
05 Sep 2014

RSC Adv., 2014,4, 43336-43340

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Palladium and copper-catalyzed ligand-free coupling of phenylhydrazines in water

P. Chauhan, M. Ravi, S. Singh, K. S. R. Raju, V. Bajpai, B. Kumar, Wahajuddin and Prem. P. Yadav, RSC Adv., 2014, 4, 43336 DOI: 10.1039/C4RA04621H

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