Issue 64, 2014
From the journal:

RSC Advances

Rhodamine-based lysosome-targeted fluorescence probes: high pH sensitivity and their imaging application in living cells†

Kang-Kang Yu,a   Kun Li,*ab   Ji-Ting Hou,a   Hui-Huan Qin,a   Yong-Mei Xie,b   Chen-Hui Qiana  and  Xiao-Qi Yu*a  

* Corresponding authors

a Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, P. R. China
E-mail: kli@scu.edu.cn, xqyu@scu.edu.cn
Fax: +86-28-85415886

b State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

Abstract

Two rhodamine-based pH probes (RhP and RhPA) were synthesized via the click reaction. The probes exhibited high pH sensitivity and selectivity with significant fluorescence intensity enhancement. Cell imaging experiments demonstrated RhPA was a good lysosome targeting probe in living cells with low cytotoxicity and excellent photostability.

Graphical abstract: Rhodamine-based lysosome-targeted fluorescence probes: high pH sensitivity and their imaging application in living cells

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Article information

DOI
https://doi.org/10.1039/C4RA05215C
Article type
Communication
Submitted
02 Jun 2014
Accepted
24 Jul 2014
First published
25 Jul 2014

RSC Adv., 2014,4, 33975-33980

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Rhodamine-based lysosome-targeted fluorescence probes: high pH sensitivity and their imaging application in living cells

K. Yu, K. Li, J. Hou, H. Qin, Y. Xie, C. Qian and X. Yu, RSC Adv., 2014, 4, 33975 DOI: 10.1039/C4RA05215C

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