Issue 82, 2014
From the journal:

RSC Advances

Metal-free syntheses of oxindole derivatives via a benzoylation/substitution/desulfonylation/cyclization cascade†

Ben Niu,a   Ping Xie,b   Wannian Zhao,a   Yang Zhou,a   Zhaogang Bian,a   Charles U. Pittman, Jr.c  and  Aihua Zhou*a  

* Corresponding authors

a Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China
E-mail: ahz@ujs.edu.cn
Fax: +86-511-85038451 ext. 806
Tel: +86-511-8503-8895 ext. 812

b Scientific Information Research Institute, Jiangsu University (Library), China

c Department of Chemistry, Mississippi State University, Mississippi State, MS 39762, USA

Abstract

A benzoylation/substitution/desulfonylation/cyclization cascade reaction giving oxindole derivatives was discovered. The reaction used aromatic aldehydes and N-alkyl-N-(phenylsulfonyl)methacrylamides as starting materials, and proceeded under mild conditions without using toxic metal catalysts. 3-Methyl-3-aroyloxindole derivatives were formed in good yields.

Graphical abstract: Metal-free syntheses of oxindole derivatives via a benzoylation/substitution/desulfonylation/cyclization cascade

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4RA06810F
Article type
Communication
Submitted
08 Jul 2014
Accepted
08 Sep 2014
First published
08 Sep 2014

RSC Adv., 2014,4, 43525-43528

Author version available

Download author version (PDF)

Permissions

Request permissions

Metal-free syntheses of oxindole derivatives via a benzoylation/substitution/desulfonylation/cyclization cascade

B. Niu, P. Xie, W. Zhao, Y. Zhou, Z. Bian, C. U. Pittman and A. Zhou, RSC Adv., 2014, 4, 43525 DOI: 10.1039/C4RA06810F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements