Direct α-C-H amination of β-dicarbonyl compounds using DBU-activated N-haloimides as nitrogen sources

Abstract

By DBU activation, N-haloimides may act as a self-immolating reagent, to convert β-dicarbonyl compounds into α-imidated products in high efficiency. The DBU/N-haloimide protocol provides a novel, mild, and complimentary access to α-imidated β-dicarbonyl compounds, without the necessity of external nitrogen sources.