Issue 66, 2014

A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes

Abstract

Synthesis of a series of novel aryl and heteroaryl fused 2,8-dioxabicyclo[3.3.1]nonanes (3) was accomplished by one pot, catalyst free reaction of 2-hydroxy chalcone (1) with 3-trifluoromethyl substituted pyrazolone (2) in xylene at reflux temperature. The role of the trifluoromethyl functional group in formation of 3 was confirmed by comparative studies with 3-methyl substituted pyrazolones (2c,d) and the outcome is presented.

Graphical abstract: A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes

Supplementary files

Article information

Article type
Paper
Submitted
01 May 2014
Accepted
29 Jul 2014
First published
06 Aug 2014

RSC Adv., 2014,4, 35009-35016

Author version available

A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes

C. Bingi, N. R. Emmadi, M. Chennapuram, J. B. Nanubolu and K. Atmakur, RSC Adv., 2014, 4, 35009 DOI: 10.1039/C4RA07278B

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