An efficient synthesis of novel dibenzoxdiazepine-fused heterocycles through a multicomponent reaction

Abstract

A one-pot synthesis of 6-oxa-2,2a¹,11-triazadibenzo[cd,g]azulenes by a three-component reaction of a 2-aminoheterocycle, aldehydes, and 2-isocyanophenyl acetate is presented. This efficient and green protocol has the advantages of environmental friendliness, high yields and operational simplicity. The atropisomeric properties of this unique structure were examined by ¹H NMR spectroscopy and X-ray structural analyses, and the barriers to their interconversion were clarified.