A simple method has been developed for the synthesis of fused isoindolines via a cascade HDDA approach catalyzed by Fe2(CO)9. In this work, a 1,3-diyne was involved in a [4 + 2] cycloisomerization with a diynophile to give an aryne intermediate, which was subsequently trapped with –OH nucleophile to beget the fused isoindolines in high yields.
J. K. Vandavasi, W. Hu, C. Hsiao, G. C. Senadi and J. Wang, RSC Adv., 2014, 4, 57547 DOI: 10.1039/C4RA12376J
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