The MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation route. The synthesis relies on efficient transformation of D-glucosamine into the orthogonally protected Tn antigen derivative and its elaboration into the TF antigen en route to MECA-79.
A. Behera, M. Emmadi and S. S. Kulkarni, RSC Adv., 2014, 4, 58573 DOI: 10.1039/C4RA12631A
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