Issue 1, 2014

Benzenesulfonyl chlorides: new reagents for access to alternative regioisomers in palladium-catalysed direct arylations of thiophenes

Abstract

The palladium-catalysed coupling of benzenesulfonyl chlorides with thiophene derivatives allows regioselective access to β-arylated thiophenes. The reaction proceeds with easily accessible catalyst, base and substrates, without oxidant or ligand and tolerates a variety of substituents on both the benzene and thiophene moieties.

Graphical abstract: Benzenesulfonyl chlorides: new reagents for access to alternative regioisomers in palladium-catalysed direct arylations of thiophenes

Supplementary files

Article information

Article type
Edge Article
Submitted
28 Aug 2013
Accepted
02 Oct 2013
First published
03 Oct 2013

Chem. Sci., 2014,5, 392-396

Benzenesulfonyl chlorides: new reagents for access to alternative regioisomers in palladium-catalysed direct arylations of thiophenes

K. Yuan and H. Doucet, Chem. Sci., 2014, 5, 392 DOI: 10.1039/C3SC52420E

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