We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.
S. R. Choi, D. Jang, S. Kim, S. An, J. Lee, E. Oh and J. Kim, J. Mater. Chem. B, 2014, 2, 616 DOI: 10.1039/C3TB21494J
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