Issue 8, 2015

Free radical-quenched SERS probes for detecting H2O2 and glucose

Abstract

For developing a free radical-quenched surface-enhanced Raman scattering (SERS) probe, starch, a linear molecule, was used as a protective layer to coat gold nanoshells (GNSs) as enhancement substrates and then, methylene blue (MB) was absorbed on the starch-coated GNSs as a free radical-responsive element. By detecting the change of the SERS intensity of MB on GNSs, the free radical-quenched SERS probes were used to detect H2O2, a less active reactive oxygen species (ROS), which was first converted to free radicals, a highly active ROS, to react with MB absorbed on GNSs to quench its SERS. The free radical-quenched SERS probe was also used to detect glucose in the presence of glucose oxidase which converted glucose to H2O2. The free radical-quenched SERS probe would be a versatile platform for detection of biochemical processes. The integration of optically changed molecules and optical enhancement of nanomaterials provided a way for advanced materials and analytical science.

Graphical abstract: Free radical-quenched SERS probes for detecting H2O2 and glucose

Article information

Article type
Paper
Submitted
21 Jan 2015
Accepted
06 Feb 2015
First published
06 Feb 2015

Analyst, 2015,140, 2741-2746

Author version available

Free radical-quenched SERS probes for detecting H2O2 and glucose

J. Dong, G. Guo, W. Xie, Y. Li, M. Zhang and W. Qian, Analyst, 2015, 140, 2741 DOI: 10.1039/C5AN00132C

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