Issue 9, 2015
From the journal:

Analyst

Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing†

F. C. Wu,abc   Y. Wu,c   Z. Niua  and  F. Vollmer*cd  

* Corresponding authors

a Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China

b University of Chinese Academy of Sciences, Beijing 100080, China

c Laboratory of Nanophotonics & Biosensing, Max Planck Institute for the Science of Light, Erlangen, Germany
E-mail: frank.vollmer@mpl.mpg.de

d Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Abstract

A label-free method is developed to ratiometrically determine the stoichiometry of oligonucleotides attached to the surface of gold nanoparticle (GNP) by whispering gallery mode biosensing. Utilizing this scheme, it is furthermore shown that the stoichiometric ratio of GNP attached oligonucleotide species can be controlled by varying the concentration ratio of thiolated oligonucleotides that are used to modify the GNP.

Graphical abstract: Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing

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Article information

DOI
https://doi.org/10.1039/C5AN00179J
Article type
Communication
Submitted
27 Jan 2015
Accepted
05 Mar 2015
First published
05 Mar 2015

Analyst, 2015,140, 2969-2972

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Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing

F. C. Wu, Y. Wu, Z. Niu and F. Vollmer, Analyst, 2015, 140, 2969 DOI: 10.1039/C5AN00179J

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