Issue 18, 2015

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

Abstract

Silver nanoparticles have been successfully applied as a matrix replacement for the laser desorption/ionization time-of-flight mass spectrometry (LDI-ToF-MS). Nanoparticles, producing spectra with highly reduced chemical background in the low m/z region, are perfectly suited for low-molecular weight compound analysis and imaging. Silver nanoparticles (AgNPs) can efficiently absorb ultraviolet laser radiation, transfer energy to the analyte and promote analyte desorption, but also constitute a source of silver ions suitable for analyte cationisation. This review provides an overview of the literature on silver nanomaterials as non-conventional desorption and ionization promoters in LDI-MS and mass spectrometry imaging.

Graphical abstract: Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

Article information

Article type
Tutorial Review
Submitted
11 May 2015
Accepted
24 Jul 2015
First published
27 Jul 2015

Analyst, 2015,140, 6195-6209

Author version available

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

J. Sekuła, J. Nizioł, W. Rode and T. Ruman, Analyst, 2015, 140, 6195 DOI: 10.1039/C5AN00943J

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