Issue 1, 2015
From the journal:

Analytical Methods

Synthesis and evaluation of a silica-bonded concanavalin A material for lectin affinity enrichment of N-linked glycoproteins and glycopeptides†

Yujie Liu,a   Dongmei Fu,ab   Yuansheng Xiao,a   Zhimou Guo,a   Long Yu*ab  and  Xinmiao Liang*a  

* Corresponding authors

a Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
E-mail: yulong@dicp.ac.cn, liangxm@dicp.ac.cn

b National Glycoengineering Research Center, Shandong University, China

Abstract

A lectin affinity chromatography material was synthesized by covalent bonding of concanavalin A onto silica gel (named SG Con A) via a rapid, simple and robust method. The material exhibited high selectivity and efficiency as well as low sample loss for the selective enrichment of N-linked glycoproteins and glycopeptides.

Graphical abstract: Synthesis and evaluation of a silica-bonded concanavalin A material for lectin affinity enrichment of N-linked glycoproteins and glycopeptides

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Article information

DOI
https://doi.org/10.1039/C4AY02286F
Article type
Communication
Submitted
26 Sep 2014
Accepted
12 Nov 2014
First published
25 Nov 2014

Anal. Methods, 2015,7, 25-28

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Synthesis and evaluation of a silica-bonded concanavalin A material for lectin affinity enrichment of N-linked glycoproteins and glycopeptides

Y. Liu, D. Fu, Y. Xiao, Z. Guo, L. Yu and X. Liang, Anal. Methods, 2015, 7, 25 DOI: 10.1039/C4AY02286F

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