Fluorescence imaging of selenol in HepG2 cell apoptosis induced by Na2SeO3

Fanpeng Kong; Bo Hu; Yan Gao; Kehua Xu; Xiaohong Pan; Fang Huang; Qiuling Zheng; Hao Chen; Bo Tang

doi:10.1039/C4CC06359G

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Fluorescence imaging of selenol in HepG2 cell apoptosis induced by Na₂SeO₃†

Fanpeng Kong,^a Bo Hu,^a Yan Gao,^a Kehua Xu,*^a Xiaohong Pan,^a Fang Huang,^a Qiuling Zheng,^b Hao Chen^b and Bo Tang*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn

^b Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, USA

Abstract

A novel fluorescence probe (HB) has been designed and synthesized to image selenol in living cells and in vivo for the first time, and used to investigate the Na₂SeO₃ anticancer mechanism in HepG2 cells.

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Article information

DOI: https://doi.org/10.1039/C4CC06359G
Article type: Communication
Submitted: 13 Aug 2014
Accepted: 02 Jan 2015
First published: 09 Jan 2015

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Chem. Commun., 2015,51, 3102-3105

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Fluorescence imaging of selenol in HepG2 cell apoptosis induced by Na₂SeO₃

F. Kong, B. Hu, Y. Gao, K. Xu, X. Pan, F. Huang, Q. Zheng, H. Chen and B. Tang, Chem. Commun., 2015, 51, 3102 DOI: 10.1039/C4CC06359G

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Chemical Communications