Issue 2, 2015
From the journal:

Chemical Communications

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells†

Y. Hakata,*a   S. Tsuchiya,b   H. Michiue,c   T. Ohtsuki,d   H. Matsui,c   M. Miyazawaa  and  M. Kitamatsu*b  

* Corresponding authors

a Department of Immunology, Faculty of Medicine, Kinki University, 377-2 Ohno-Higashi, Sayama, Osaka 589-8511, Japan
E-mail: hakata@med.kindai.ac.jp
Tel: +81-72-366-0221

b Department of Applied Chemistry, Faculty of Science and Engineering Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan
E-mail: kitamatu@apch.kindai.ac.jp
Tel: +81-6-6721-2332

c Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, kita-ku, Okayama 700-8558, Japan

d Department of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, kita-ku, Okayama 700-8530, Japan

Abstract

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death.

Graphical abstract: A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

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Article information

DOI
https://doi.org/10.1039/C4CC07459A
Article type
Communication
Submitted
22 Sep 2014
Accepted
06 Nov 2014
First published
18 Nov 2014

Chem. Commun., 2015,51, 413-416

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A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata, S. Tsuchiya, H. Michiue, T. Ohtsuki, H. Matsui, M. Miyazawa and M. Kitamatsu, Chem. Commun., 2015, 51, 413 DOI: 10.1039/C4CC07459A

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