Issue 2, 2015
From the journal:

Chemical Communications

Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles†

Shuqing He,a   Kristina Krippes,a   Sandra Ritz,a   Zhijun Chen,a   Andreas Best,a   Hans-Jürgen Butt,a   Volker Mailänderab  and  Si Wu*a  

* Corresponding authors

a Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
E-mail: wusi@mpip-mainz.mpg.de

b III. Medical Clinic, University Medicine of the Johannes-Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany

Abstract

Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm−2. Such low light intensity minimized overheating problems and prevented photodamage to biological samples.

Graphical abstract: Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

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Article information

DOI
https://doi.org/10.1039/C4CC07489K
Article type
Communication
Submitted
22 Sep 2014
Accepted
11 Nov 2014
First published
11 Nov 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 431-434

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Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

S. He, K. Krippes, S. Ritz, Z. Chen, A. Best, H. Butt, V. Mailänder and S. Wu, Chem. Commun., 2015, 51, 431 DOI: 10.1039/C4CC07489K

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