Issue 1, 2015
From the journal:

Chemical Communications

Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease†

Guanglei Lv,a   Baiping Cui,b   Haichuang Lan,a   Ying Wen,a   Anyang Sun*b  and  Tao Yi*a  

* Corresponding authors

a Department of Chemistry & Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China
E-mail: yitao@fudan.edu.cn
Fax: +86-21-55664621

b Laboratory of Neurodegenerative Diseases and Repair, Yancheng Institute of Health Sciences, 263 South Jiefang Road, Yancheng 224005, Jiangsu, P. R. China
E-mail: anyangsun@hotmail.com

Abstract

Two fluorescent switchable diarylethene derivatives which exhibit high affinity for amyloid-β aggregates with the increase of fluorescence intensity were reported. Moreover, the probes show excellent photochromic and anti-photobleaching properties both in vitro and in vivo.

Graphical abstract: Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C4CC07656G
Article type
Communication
Submitted
28 Sep 2014
Accepted
04 Nov 2014
First published
04 Nov 2014

Chem. Commun., 2015,51, 125-128

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Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease

G. Lv, B. Cui, H. Lan, Y. Wen, A. Sun and T. Yi, Chem. Commun., 2015, 51, 125 DOI: 10.1039/C4CC07656G

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