Issue 5, 2015
From the journal:

Chemical Communications

Plasmonic metal scattering immunoassay by total internal reflection scattering microscopy with nanoscale lateral resolution†

Seungah Lee,a   Hyunung Yub  and  Seong Ho Kang*a  

* Corresponding authors

a Department of Applied Chemistry, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea
E-mail: shkang@khu.ac.kr
Fax: +82 31 201 2340
Tel: +82 31 201 3349

b Nanobio Fusion Research Center, Korea Research Institute of Standards and Science, Daejeon 305-600, Republic of Korea

Abstract

Immunoassays on nanopatterned chips through TIRS detection based on reconstructing the three dimensional position provided a nanoscale accuracy of the lateral resolution by using the z-stage controller in the spatial range up to 10 nm. This method offers highly accurate and sensitive quantification with the zeptomolar (∼10−21 M) detection of proteins.

Graphical abstract: Plasmonic metal scattering immunoassay by total internal reflection scattering microscopy with nanoscale lateral resolution

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Article information

DOI
https://doi.org/10.1039/C4CC07665F
Article type
Communication
Submitted
29 Sep 2014
Accepted
24 Nov 2014
First published
24 Nov 2014

Chem. Commun., 2015,51, 945-947

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Plasmonic metal scattering immunoassay by total internal reflection scattering microscopy with nanoscale lateral resolution

S. Lee, H. Yu and S. H. Kang, Chem. Commun., 2015, 51, 945 DOI: 10.1039/C4CC07665F

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