Issue 6, 2015
From the journal:

Chemical Communications

Binary behaviour of an oxidation-responsive MRI nano contrast agent†

Damien Jeanmaire,a   Grigore A. Timco,b   Arianna Gennari,c   Stephen Sproules,‡b   Kaye J. Williams,ad   Richard E. P. Winpennyb  and  Nicola Tirelli*ce  

* Corresponding authors

a Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester M13 9PT, UK

b School of Chemistry, University of Manchester, Brunswick Street, Manchester, UK

c Institute of Inflammation & Repair, University of Manchester, Oxford Road, Manchester M13 9PT, UK
E-mail: nicola.tirelli@manchester.ac.uk

d CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester, UK

e School of Materials, University of Manchester, Grosvenor Street, Manchester, UK

Abstract

A new nano contrast agent has been prepared incorporating a molecular magnet in oxidation-responsive nanoparticles; this system has shown a remarkable sensitivity to hydrogen peroxide (detection down to at least 40 μM), which was used as a model reactive oxygen species. Surprisingly, the response had a binary (off/on) character, due to a non-linear cascade relation between extent of oxidation and water permeability in the particles.

Graphical abstract: Binary behaviour of an oxidation-responsive MRI nano contrast agent

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Article information

DOI
https://doi.org/10.1039/C4CC08024F
Article type
Communication
Submitted
10 Oct 2014
Accepted
20 Nov 2014
First published
21 Nov 2014

Chem. Commun., 2015,51, 1074-1076

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Binary behaviour of an oxidation-responsive MRI nano contrast agent

D. Jeanmaire, G. A. Timco, A. Gennari, S. Sproules, K. J. Williams, R. E. P. Winpenny and N. Tirelli, Chem. Commun., 2015, 51, 1074 DOI: 10.1039/C4CC08024F

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