This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and site-selective protein labeling.
R. Singudas, S. R. Adusumalli, P. N. Joshi and V. Rai, Chem. Commun., 2015, 51, 473 DOI: 10.1039/C4CC08503E
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