Selective disruption of each part of Janus molecular assemblies by lateral diffusion of stimuli-responsive amphiphilic peptides

Abstract

Stimuli-responsive Janus-type assemblies with a round-bottom flask shape are prepared from amphiphilic helical peptides using the patchwork self-assembly technique. It can disassemble selectively at the neck or the round-bottom part of the Janus assemblies at low pH upon heat treatment accompanied by the lateral diffusion of the peptides.