The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.
B. Wang, J. Fan, X. Wang, H. Zhu, J. Wang, H. Mu and X. Peng, Chem. Commun., 2015, 51, 792 DOI: 10.1039/C4CC08915D
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