Regioselective Csp2–H dual functionalization of indoles using hypervalent iodine(iii): bromo-amination via 1,3-migration of imides on indolyl(phenyl)iodonium imides

Abstract

A regioselective C_sp²–H dual functionalization of indoles, which underlies bromo-amination via the 1,3-migration of imide groups on indolyl(phenyl)iodonium imides as novel imide-combined hypervalent iodines(III), has been developed to provide 2-bis(sulfonyl)amino-3-bromo-indoles under the metal-free conditions.