Issue 9, 2015
From the journal:

Chemical Communications

Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions†

L. Margarucci,a   M. C. Monti,*a   A. Tosco,a   R. Esposito,a   A. Zampella,b   V. Sepe,b   M. Mozzicafreddo,c   R. Riccioa  and  A. Casapullo*a  

* Corresponding authors

a Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano, Salerno, Italy
E-mail: mcmonti@unisa.it, casapullo@unisa.it

b Department of Pharmacy, University of Napoli “Federico II”, Via Montesanto, Naples, Italy

c School of Biosciences and Veterinary Medicine, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy

Abstract

Peroxiredoxin-1, a key enzyme in the cellular detoxification pathway, has been identified through a chemoproteomic approach as the main partner of theonellasterone, a marine bioactive metabolite. A combination of chemical and biochemical assays disclosed its mechanism of action at the molecular level.

Graphical abstract: Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions

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Article information

DOI
https://doi.org/10.1039/C4CC09205H
Article type
Communication
Submitted
18 Nov 2014
Accepted
03 Dec 2014
First published
08 Dec 2014

Chem. Commun., 2015,51, 1591-1593

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Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions

L. Margarucci, M. C. Monti, A. Tosco, R. Esposito, A. Zampella, V. Sepe, M. Mozzicafreddo, R. Riccio and A. Casapullo, Chem. Commun., 2015, 51, 1591 DOI: 10.1039/C4CC09205H

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