The utilization of copper flow reactors in organic synthesis

Abstract

The use of flow chemistry techniques has flourished over the past decade, with the field expanding to include the use of copper flow reactors in bench-top organic synthesis in recent years. These reactors are available in a variety of forms and possess a number of advantages over their batch reaction counterparts, in terms of both safety and yield. This review will highlight the current research employing copper flow reactors, such as 1,3-dipolar cycloadditions (‘click’ chemistry), macrocyclizations (via ‘click’ chemistry), Sonogashira C–C couplings, Ullmann couplings, decarboxylations, and other reported findings.