Issue 12, 2015
From the journal:

Chemical Communications

Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles†

Daniel Hack,a   Pankaj Chauhan,a   Kristina Deckers,a   Yusuke Mizutani,b   Gerhard Raabea  and  Dieter Enders*a  

* Corresponding authors

a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
E-mail: enders@rwth-aachen.de

b Nara Institute of Science and Technology (NAIST), Ikoma, Japan

Abstract

A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee).

Graphical abstract: Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

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Article information

DOI
https://doi.org/10.1039/C4CC09495F
Article type
Communication
Submitted
27 Nov 2014
Accepted
23 Dec 2014
First published
23 Dec 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 2266-2269

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Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

D. Hack, P. Chauhan, K. Deckers, Y. Mizutani, G. Raabe and D. Enders, Chem. Commun., 2015, 51, 2266 DOI: 10.1039/C4CC09495F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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