Issue 14, 2015

Cationic fluorescent polymer core–shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA

Abstract

A multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core–shell nanoparticles. The nanocarrier has good biocompatibility and high transfection efficiency over the most popular transfection reagent, Lipofectamine 2000. Fluorescence resonance energy transfer within the nanocarrier provides a non-invasive and label-free method to track the intracellular release of siRNA.

Graphical abstract: Cationic fluorescent polymer core–shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA

Supplementary files

Article information

Article type
Communication
Submitted
04 Dec 2014
Accepted
13 Jan 2015
First published
13 Jan 2015

Chem. Commun., 2015,51, 2976-2979

Cationic fluorescent polymer core–shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA

J. Yu, S. Zhu, P. Feng, C. Qian, J. Huang, M. Sun and Q. Shen, Chem. Commun., 2015, 51, 2976 DOI: 10.1039/C4CC09685A

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