Issue 18, 2015
From the journal:

Chemical Communications

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods†

Stefania Ordanini,a   Norbert Varga,a   Vanessa Porkolab,bcd   Michel Thépaut,bcd   Laura Belvisi,ae   Andrea Bertaglia,a   Alessandro Palmioli,a   Angela Berzi,f   Daria Trabattoni,f   Mario Clerici,gh   Franck Fieschibcd  and  Anna Bernardi*ae  

* Corresponding authors

a Università degli Studi di Milano (UniMI), Dip. Chimica, via Golgi 19, 20133, Milano, Italy
E-mail: anna.bernardi@unimi.it
Tel: +39 02 50314092

b Univ. Grenoble Alpes, Inst. de Biologie Structurale, Grenoble, France

c CNRS, IBS, F-38044, Grenoble, France

d CEA, IBS, F-38044 Grenoble, France

e CNR-ISTM, Inst. of Molecular Science and Technologies, Milano, Italy

f UniMI, Dip. Scienze Biomediche e Cliniche “L. Sacco”, Milano, Italy

g UniMI, Dip. Fisiopatologia Medico-Chirurgica e Trapianti, Segrate, Italy

h Fondazione Don Carlo Gnocchi IRCCS, Milano, Italy

Abstract

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

Graphical abstract: Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

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Article information

DOI
https://doi.org/10.1039/C4CC09709B
Article type
Communication
Submitted
11 Dec 2014
Accepted
28 Jan 2015
First published
28 Jan 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 3816-3819

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Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

S. Ordanini, N. Varga, V. Porkolab, M. Thépaut, L. Belvisi, A. Bertaglia, A. Palmioli, A. Berzi, D. Trabattoni, M. Clerici, F. Fieschi and A. Bernardi, Chem. Commun., 2015, 51, 3816 DOI: 10.1039/C4CC09709B

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