Issue 20, 2015
From the journal:

Chemical Communications

Manipulation of ionic liquid anion–solute–antisolvent interactions for the purification of acetaminophen†

C. C. Weber,a   A. J. Kunov-Kruse,a   R. D. Rogersb  and  A. S. Myerson*a  

* Corresponding authors

a Novartis-MIT Center for Continuous Manufacturing and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
E-mail: myerson@mit.edu

b Center for Green Manufacturing and Department of Chemistry, The University of Alabama, Tuscaloosa, Alabama, USA

Abstract

Hydrogen bond donating cosolvents have been shown to significantly reduce the solubility of acetaminophen (AAP) in ionic liquids containing the acetate anion. Reduced solubility arises from competition for solvation by the acetate anion and can be used for the design of advanced separation techniques, illustrated by the crystallization of AAP.

Graphical abstract: Manipulation of ionic liquid anion–solute–antisolvent interactions for the purification of acetaminophen

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Article information

DOI
https://doi.org/10.1039/C5CC00198F
Article type
Communication
Submitted
09 Jan 2015
Accepted
02 Feb 2015
First published
03 Feb 2015

Chem. Commun., 2015,51, 4294-4297

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Manipulation of ionic liquid anion–solute–antisolvent interactions for the purification of acetaminophen

C. C. Weber, A. J. Kunov-Kruse, R. D. Rogers and A. S. Myerson, Chem. Commun., 2015, 51, 4294 DOI: 10.1039/C5CC00198F

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