A multiple gadolinium complex decorated fullerene as a highly sensitive T1 contrast agent

Lirong Wang; Xianglong Zhu; Xingyan Tang; Changqiang Wu; Zijian Zhou; Chengjie Sun; Shun-Liu Deng; Hua Ai; Jinhao Gao

doi:10.1039/C5CC00285K

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A multiple gadolinium complex decorated fullerene as a highly sensitive T₁ contrast agent†

Lirong Wang,^a Xianglong Zhu,^a Xingyan Tang,^a Changqiang Wu,^b Zijian Zhou,^a Chengjie Sun,^a Shun-Liu Deng,^a Hua Ai^b and Jinhao Gao*^a

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* Corresponding authors

^a State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: jhgao@xmu.edu.cn
Fax: +86-592-2189959
Tel: +86-592-2180278

^b National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu 610064, P. R. China

Abstract

We report a simple strategy to construct a multiple gadolinium complex decorated fullerene (CGD_n) as an enhanced T₁ contrast agent. The CGD_n exhibits much higher T₁ relaxivity (∼49.7 mM⁻¹ s⁻¹) than individual Gd-DOTA, and shows excellent T₁ contrast enhancement ability both in vitro and in vivo.

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Article information

DOI: https://doi.org/10.1039/C5CC00285K
Article type: Communication
Submitted: 12 Jan 2015
Accepted: 03 Feb 2015
First published: 03 Feb 2015

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Chem. Commun., 2015,51, 4390-4393

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A multiple gadolinium complex decorated fullerene as a highly sensitive T₁ contrast agent

L. Wang, X. Zhu, X. Tang, C. Wu, Z. Zhou, C. Sun, S. Deng, H. Ai and J. Gao, Chem. Commun., 2015, 51, 4390 DOI: 10.1039/C5CC00285K

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