We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.
R. He, Y. Huang, C. Chiang, Y. Tsai, T. Ye, H. Gao, C. Wu, H. Lee and J. J. Huang, Chem. Commun., 2015, 51, 8652 DOI: 10.1039/C5CC00513B
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