A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells

Batakrishna Jana; Jayita Sarkar; Prasenjit Mondal; Surajit Barman; Saswat Mohapatra; Debmalya Bhunia; Krishnangsu Pradhan; Abhijit Saha; Anindyasundar Adak; Subhajit Ghosh; Surajit Ghosh

doi:10.1039/C5CC03432A

A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells†

Batakrishna Jana,^a Jayita Sarkar,^a Prasenjit Mondal,^b Surajit Barman,^a Saswat Mohapatra,^b Debmalya Bhunia,^a Krishnangsu Pradhan,^a Abhijit Saha,^a Anindyasundar Adak,^a Subhajit Ghosh^a and Surajit Ghosh*^ab

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^a Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India
E-mail: sghosh@iicb.res.in
Fax: +91-33-2473-5197/0284
Tel: +91-33-2499-5872

^b Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4 Raja S. C. Mullick Road, Kolkata 700 032, India

Abstract

A short GC rich DNA derived from microbial origin interacts with tubulin/microtubules activates p53 over expression and induces apoptotic death of human breast cancer (MCF-7) cells.

Chemical Communications

A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells†

Abstract

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A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells

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