Issue 60, 2015
From the journal:

Chemical Communications

An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole†‡

Xue-Qing Mou,a   Zheng-Liang Xu,a   Shao-Hua Wang,*ab   Dao-Yong Zhu,a   Jie Wang,a   Wen Bao,a   Shi-Jiang Zhou,a   Chao Yanga  and  Di Zhanga  

* Corresponding authors

a School of Pharmacy & State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, P. R. China
E-mail: wangshh@lzu.edu.cn

b Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, Sichuan University, Chengdu, P. R. China

Abstract

An Au(I)-catalyzed tandem reaction for the synthesis of 2-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole derivatives from 1-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclobutanol and primary amines or NH4OAc has been developed to afford a series of polysubstituted pyrroles in moderate to good yields.

Graphical abstract: An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole

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Article information

DOI
https://doi.org/10.1039/C5CC03979G
Article type
Communication
Submitted
13 May 2015
Accepted
12 Jun 2015
First published
12 Jun 2015

Chem. Commun., 2015,51, 12064-12067

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An Au(I)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole

X. Mou, Z. Xu, S. Wang, D. Zhu, J. Wang, W. Bao, S. Zhou, C. Yang and D. Zhang, Chem. Commun., 2015, 51, 12064 DOI: 10.1039/C5CC03979G

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