Issue 59, 2015
From the journal:

Chemical Communications

Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe†

Lei Dong,‡a   Yi Zang,‡b   Dan Zhou,ab   Xiao-Peng He,*a   Guo-Rong Chen,a   Tony D. Jamesc  and  Jia Li*b  

* Corresponding authors

a Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

b National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China
E-mail: jli@simm.ac.cn

c Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

Abstract

With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.

Graphical abstract: Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

About
Cited by
Related
Download options Please wait...

Associated articles

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC04357C
Article type
Communication
Submitted
27 May 2015
Accepted
18 Jun 2015
First published
18 Jun 2015

Chem. Commun., 2015,51, 11852-11855

Permissions

Request permissions

Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

L. Dong, Y. Zang, D. Zhou, X. He, G. Chen, T. D. James and J. Li, Chem. Commun., 2015, 51, 11852 DOI: 10.1039/C5CC04357C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements