Issue 59, 2015
From the journal:

Chemical Communications

Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes†

Xinxin Wu,a   Chunna Meng,a   Xiaoqian Yuan,a   Xiaotong Jia,b   Xuhong Qianb  and  Jinxing Ye*ac  

* Corresponding authors

a Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Load, Shanghai 200237, China
E-mail: yejx@ecust.edu.cn

b Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Load, Shanghai 200237, China

c Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Load, Shanghai 200237, China

Abstract

We report herein an efficient, general and green method for decarboxylative fluorination of aliphatic carboxylic acids. By using a transition-metal-free, organocatalytic photoredox system, the reaction of various aliphatic carboxylic acids with the Selectfluor reagent afforded the corresponding alkyl fluorides in satisfactory yields under visible light irradiation at room temperature.

Graphical abstract: Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes

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Article information

DOI
https://doi.org/10.1039/C5CC04527D
Article type
Communication
Submitted
02 Jun 2015
Accepted
18 Jun 2015
First published
18 Jun 2015

Chem. Commun., 2015,51, 11864-11867

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Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes

X. Wu, C. Meng, X. Yuan, X. Jia, X. Qian and J. Ye, Chem. Commun., 2015, 51, 11864 DOI: 10.1039/C5CC04527D

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