A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

Abstract

In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a M_W of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified β-cyclodextrin) 60 fold, yet cause no increase in toxicity.