Issue 74, 2015
From the journal:

Chemical Communications

Application of Good's buffers to pH imaging using hyperpolarized 13C MRI†

Robert R. Flavell, ORCID logo a   Cornelius von Morze,a   Joseph E. Blecha,a   David E. Korenchan,a   Mark Van Criekinge,a   Renuka Sriram,a   Jeremy W. Gordon,a   Hsin-Yu Chen,a   Sukumar Subramaniam,a   Robert A. Bok,a   Zhen J. Wang,a   Daniel B. Vigneron,a   Peder E. Larson,a   John Kurhanewicza  and  David M. Wilson*a  

* Corresponding authors

a Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158, USA
E-mail: David.m.wilson@ucsf.edu

Abstract

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range.

Graphical abstract: Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

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Article information

DOI
https://doi.org/10.1039/C5CC05348J
Article type
Communication
Submitted
29 Jun 2015
Accepted
03 Aug 2015
First published
03 Aug 2015

Chem. Commun., 2015,51, 14119-14122

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Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

R. R. Flavell, C. von Morze, J. E. Blecha, D. E. Korenchan, M. Van Criekinge, R. Sriram, J. W. Gordon, H. Chen, S. Subramaniam, R. A. Bok, Z. J. Wang, D. B. Vigneron, P. E. Larson, J. Kurhanewicz and D. M. Wilson, Chem. Commun., 2015, 51, 14119 DOI: 10.1039/C5CC05348J

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