Issue 76, 2015

Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles

Abstract

Circular dichroism spectroscopy has been explored for detection of methyltransferase activity and inhibition based on DNA-induced chiroplasmonic assemblies of gold nanoparticles and endonuclease HpaII. Good accuracy, precision and sensitivity are obtained in complex matrices such as human serum samples, which is significant for clinical diagnosis and drug development.

Graphical abstract: Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Chem. Commun., 2015,51, 14350-14353

Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles

Y. Liu, M. Wei, L. Zhang, W. Wei, Y. Zhang and S. Liu, Chem. Commun., 2015, 51, 14350 DOI: 10.1039/C5CC05375G

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