Issue 92, 2015
From the journal:

Chemical Communications

Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance†

Roya Tavallaie,abc   Nadim Darwish,a   D. Brynn Hibberta  and  J. Justin Gooding*abc  

* Corresponding authors

a School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia
E-mail: Justin.gooding@unsw.edu.au
Fax: +61 2 9385 6141
Tel: +61 2 9385 5384

b Australian Centre for NanoMedicine, The University of New South Wales, Sydney, NSW 2052, Australia

c ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia

Abstract

The influence of RNA versus DNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.

Graphical abstract: Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

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Article information

DOI
https://doi.org/10.1039/C5CC05450H
Article type
Communication
Submitted
02 Jul 2015
Accepted
22 Sep 2015
First published
30 Sep 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 16526-16529

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Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

R. Tavallaie, N. Darwish, D. Brynn Hibbert and J. Justin Gooding, Chem. Commun., 2015, 51, 16526 DOI: 10.1039/C5CC05450H

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