Issue 78, 2015
From the journal:

Chemical Communications

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide†

J.-M. Swiecicki,‡abc   M. Di Pisa,‡abc   F. Lippi,abc   S. Chwetzoff,acdef   C. Mansuy,abc   G. Trugnan,acde   G. Chassaing,abc   S. Lavielle*abc  and  F. Burlina*abc  

* Corresponding authors

a Sorbonne Universités, UPMC Univ Paris 06, Laboratoire des Biomolécules, UMR 7203, 4, Place Jussieu 75005, Paris, France
E-mail: solange.lavielle@upmc.fr, fabienne.burlina@upmc.fr

b Ecole Normale Supérieure – PSL Research University Institution, Département de Chimie, 24, Rue Lhomond, 75005 Paris, France

c CNRS – UMR7203, Paris, France

d INSERM – ERL 1157, Paris, France

e AP-HP, Hôpital Saint Antoine, 75012 Paris, France

f INRA, UR892, Virologie et Immunologie Moléculaires, 78350, Jouy-en-Jossas, France

Abstract

The recurring issue with cell penetrating peptides is how to increase direct translocation vs. endocytosis, to avoid premature degradation. Acylation by a cis unsaturated chain (C22:6) of a short cationic peptide provides a new rational design to favour diffuse cytosolic and dense Golgi localisations.

Graphical abstract: Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

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Article information

DOI
https://doi.org/10.1039/C5CC06116D
Article type
Communication
Submitted
22 Jul 2015
Accepted
12 Aug 2015
First published
14 Aug 2015

Chem. Commun., 2015,51, 14656-14659

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Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

J.-M. Swiecicki, M. Di Pisa, F. Lippi, S. Chwetzoff, C. Mansuy, G. Trugnan, G. Chassaing, S. Lavielle and F. Burlina, Chem. Commun., 2015, 51, 14656 DOI: 10.1039/C5CC06116D

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