Issue 78, 2015
From the journal:

Chemical Communications

Highly sensitive “signal-on” electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction†

Jing Lou,‡a   Zhaoyin Wang,‡a   Xiao Wang,a   Jianchun Bao,a   Wenwen Tua  and  Zhihui Dai*a  

* Corresponding authors

a Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China
E-mail: daizhihuii@njnu.edu.cn
Fax: +86-25-85891051
Tel: +86-25-85891051

Abstract

A “signal-on” electrochemiluminescent DNA biosensing platform was proposed based on the dual quenching and strand displacement reaction. This novel “signal-on” detection strategy revealed its sensitivity in achieving a detection limit of 2.4 aM and its selectivity in distinguishing single nucleotide polymorphism of target DNA.

Graphical abstract: Highly sensitive “signal-on” electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

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Article information

DOI
https://doi.org/10.1039/C5CC06156C
Article type
Communication
Submitted
23 Jul 2015
Accepted
10 Aug 2015
First published
11 Aug 2015

Chem. Commun., 2015,51, 14578-14581

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Highly sensitive “signal-on” electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

J. Lou, Z. Wang, X. Wang, J. Bao, W. Tu and Z. Dai, Chem. Commun., 2015, 51, 14578 DOI: 10.1039/C5CC06156C

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