Issue 78, 2015
From the journal:

Chemical Communications

Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components†

Mariam Samadi Moghaddam,a   Markus Heinyab  and  V. Prasad Shastri*ab  

* Corresponding authors

a Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Str. 31, 79104 Freiburg, Germany
E-mail: prasad.shastri@gmail.com

b BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestr. 18, 79104 Freiburg, Germany

Abstract

The influence of hydrophobicity on the internalization of polymeric nanoparticles (NPs) remains poorly investigated. The hydrophobicity of poly(L-lactide) was increased by copolymerization with cell-membrane-lipid components, and this significantly enhanced the uptake of NPs up to 60% in the human cervical cancer cell line in comparison to unmodified poly(L-lactide) NPs.

Graphical abstract: Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components

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Article information

DOI
https://doi.org/10.1039/C5CC06397C
Article type
Communication
Submitted
30 Jul 2015
Accepted
10 Aug 2015
First published
10 Aug 2015

Chem. Commun., 2015,51, 14605-14608

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Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components

M. Samadi Moghaddam, M. Heiny and V. P. Shastri, Chem. Commun., 2015, 51, 14605 DOI: 10.1039/C5CC06397C

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