CF3-Substituted semisquarate: a pluripotent building block for the divergent synthesis of trifluoromethylated functional molecules

Abstract

The first synthesis of a CF₃-substituted semisquarate was accomplished via nucleophilic trifluoromethylation using CF₃SiMe₃ and subsequent rhenium-catalyzed allylic alcohol rearrangement. The short-step skeletal-divergent synthesis of trifluoromethylated functional molecules was successfully achieved using the CF₃-substituted semisquarate as the platform.