Issue 100, 2015
From the journal:

Chemical Communications

Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes†

Ian William Hamley,*a   Steven Kirkham,a   Radoslaw M. Kowalczyk,a   Valeria Castelletto,a   Mehedi Rezab  and  Janne Ruokolainenb  

* Corresponding authors

a School of Chemistry, Pharmacy and Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK
E-mail: i.w.hamley@reading.ac.uk

b Dept. of Applied Physics, Aalto University School of Science, P. O. Box 15100, Finland

Abstract

The amphiphilic polyene amphotericin B, a powerful treatment for systemic fungal infections, is shown to exhibit a critical aggregation concentration, and to form giant helically-twisted nanostructures via self-assembly in basic aqueous solution.

Graphical abstract: Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes

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Article information

DOI
https://doi.org/10.1039/C5CC08224B
Article type
Communication
Submitted
02 Oct 2015
Accepted
20 Oct 2015
First published
20 Oct 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 17680-17683

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Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes

I. W. Hamley, S. Kirkham, R. M. Kowalczyk, V. Castelletto, M. Reza and J. Ruokolainen, Chem. Commun., 2015, 51, 17680 DOI: 10.1039/C5CC08224B

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