Issue 7, 2015

Progress in asymmetric biomimetic transamination of carbonyl compounds

Abstract

Transamination of α-keto acids with transaminases and pyridoxamine phosphate is an important process to form optically active α-amino acids in biological systems. Various biomimetic transamination systems have been developed for carbonyl compounds including α-keto acid derivatives, fluoroalkyl ketones, and unactivated ketones with chiral vitamin B6 analogues, artificial transaminase mimics, chiral nitrogen sources, and chiral catalysts. This review provides a brief summary of this area.

Graphical abstract: Progress in asymmetric biomimetic transamination of carbonyl compounds

Article information

Article type
Tutorial Review
Submitted
22 Dec 2014
First published
03 Feb 2015

Chem. Soc. Rev., 2015,44, 1740-1748

Author version available

Progress in asymmetric biomimetic transamination of carbonyl compounds

Y. Xie, H. Pan, M. Liu, X. Xiao and Y. Shi, Chem. Soc. Rev., 2015, 44, 1740 DOI: 10.1039/C4CS00507D

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